ISRAEL 
HIGH-TECH & INVESTMENT REPORT

from the July 2006 issue


Leading Medical Technology Companies

Atria Medical Inc
Sector: Medical Devices
Sub-Sector: Disposable; Implantable; Therapeutic Devices Medical Field: Cardiovascular
Est.: 2004
Stage: Seed
Atria is a start-up company developing an implantable device to enhance and improve the clinical symptoms of Congestive Heart Failure patients by reducing pulmonary edema. The company's product is an implantable "valve" to control the intra-arterial pressure. The device is implanted by aminimally invasive procedure in the wall separating the two atria.
Contact Info:
Ori Ben Amotz
POB 3132 Caessaria 38900, Israel
972-4-632-7640/1

Biobeat Medical Ltd.
Sector: Medical Devices
Sub-Sector: Diagnostic
Medical Field: Cardiovascular
Est.: 2004
Stage: Revenue
http://biobeatmedical.com
Biobeat Medical develops and markets special ultrasound Doppler devices for transcranial (TCD) and peripheral vascular applications. The company's core technology is digital ultrasound Doppler, and its' products are designed for measurements of blood flow velocities in the vessels of the brain and the peripheral circulation. The company's products include the SONARA, a fully integrated stand-alone system, and the SONARA/tek, a plug-in module that can connect to any PC via a USB connection. The products are regulatory approved, and Biobeat Medical conforms to the highest QA standards.
Contact Info:
Dr. Dan Manor, CEO
info@biobeatmedical.com
P.O. Box 264, Kadima, Israel
972-9-744-1692
972-9-745-0621

Bioscan Technologies
Sector: Medical Devices
Sub-Sector: Diagnostic
Medical Field: Cardiovascular
Est.: 2000
Stage: Clinical
http://www.bioscantech.com
Bioscan is a start-up company focusing on the development of optical ultrasonic technology for the use in diagnosis and treatment of cardiovascular diseases. The company's platform technology, SonarLight, combines the use of a laser and ultrasound technology operating within a fiber optic. By utilizing laser to generate ultrasound, Bioscan is expected to be able to reduce the size of its ultrasound probe to that of an optic fiber thereby transforming the diagnosis and treatment of intravascular diseases. The low production costs of fiber optic technology will allow for competitive pricing of disposables compared to existing technologies.
Contact Info:
Avram Matcovitch, CEO
Ha'Carmel 5, Industrial Zone, Yokneam, 20692 Israel
972-4-993-7363

DECOM Clinical Decision Support Ltd.
Sector: Medical Devices
Sub-Sector: Imaging
Medical Field: Cardiovascular
Est.: 2004
Stage: Seed
http://www.decomcds.com
DECOM Clinical Decision Support Ltd. - a medical software company develops and offers the dCARDIO product suite - a patient-centric diagnostic image and information management solution to both OEMs and end users - cardiology group practices, small hospitals, imaging centers, and solo practitioners.
Incorporating data from diverse institutions, dCARDIO makes all patient's diagnostic images accessible at the point of care - Anytime and Anywhere. With dCARDIO, review workstation functionality traditionally existing only in diagnostic labs, becomes available in every physician's office. The ability to maintain a personal image collection on physician's laptop makes the product core functionality portable.
Due to its versatile architecture, the core product can be integrated with electronic medical record systems in a single application. As a result, physicians review, compare and analyze patient's diagnostic images along with the electronic medical record, facilitating the efficient detection of changes in the clinical situation.
The company's mission is to become a market leader in delivering diagnostic decision support tools for cardiology practitioners.
Contact Info:
Vladimir Boyko, President
info@decomcds.com
P.O.Box 421, Kiryat Ono, 55000
972-54-459-0589
972-3-534-8918

TopSpin Medical Inc.
Sector: Medical Devices
Sub-Sector: Imaging
Medical Field: Cardiovascular
Est.: 1999
Stage: Clinical
http://www.topspin.co.il
TopSpin Medical has developed an IntraVascular MRI (IVMRI) catheter for local high-resolution MR imaging of the coronary arteries, which incorporates all magnetic field sources and eliminates the need for external magnets and a bulky and expensive MRI scanner. TopSpin's IVMRI catheter will potentially enable interventional cardiologists to guide therapy to vulnerable plaques.
Contact Info:
Eyal Kolka, COO
info@topspin.co.il
2 Yodfat St. Global Park, Lod Northern Industrial Area 71291, Israel
972-8-920-0033
972-8-928-1233
imaging of the coronary arteries.

Rcadia Medical Imaging Ltd.
Sector: Medical IT
Sub-Sector: Software and Hardware
Medical Field: Cardiovascular
Est.: 2003
Stage: Seed
http://www.rcadia.com
Rcadia is engaged in the development of SmartHeart - a software for automated CT Angiography (CTA) diagnostics for the detection, assessment and reporting of Coronary Artery Disease.
Rcadia specializes in CAD (Computer Aided Diagnostics) for blood vessel analysis applications. While the main focus is on coronary CTA, we aim to offer a wider range of solutions for additional clinical applications. For the first time, CT scanners can image lesions of the native coronary arteries with unprecedented clarity and resolution - a vital and unique breakthrough in the radiology and cardiology fields. Rcadia's SmartHeart CAD will play a pivotal role in this revolution. SmartHeart, Rcadia's CTA flagship product will assist cardiologists and radiologists in medical image analysis to:
Detect calcified plaque, soft plaque, stenosis & aneurysm
Measure the volume of plaque formations
Segment and locate blood vessels in CT studies
Measure the degree of stenosis/aneurysm
Map pathology locations in anatomical structures (segments)
Contact Info:
Shai Levanon, CEO
2 Hayozma, Tirat Carmel 39032, Israel
+972-4-8583010
+972-4-8582070

Actelion Pharmaceuticals Israel
Sector: Pharmaceuticals
Sub-Sector: New Chemical Entity
Medical Field: Cardiovascular
Est.: 2004
Stage: Revenue
http://www.actelion.com
Actelion is an indepedent biopharmaceutical company which brings to the market innovative treatments for diseases of endothelium through creative science. The company is rapidly growing due to successful marketing of multiple first-in-class small molecule compounds discovered, developed and registered by the company. On 2004 Actelion has opended an Israeli subsidiary.
Contact Info:
Ran Frenkel, CEO
efrat.gur@actelion.com
3 Hayetzira St. Ramat-Gan 52521 Israel
972-3-612-5500
972-3-612-6600

Vascular Biogenics Ltd.
Sector: Pharmaceuticals
Sub-Sector: New Chemical Entity
Medical Field: Cardiovascular
Est.: 2000
Stage: Pre-Clinical
http://www.vbl.co.il
Vascular Biogenics Ltd. (VBL) is a pharmaceutical company dedicated to the development of innovative therapies targeting the vascular wall. Its extensive vascular expertise is utilized in addressing the Cardiovascular and Cancer drug markets.
Contact Info:
Dr. Emmanuel Elalouf, COO
contact@vbl.co.il
6 Jonathan Netanyahu, Or Yehuda, 60376 Israel
972-3-634-6450 (Ext. 103)
972-3-634-6449

MGVS
Sector: Biotechnology
Sub-Sector: Tissue Engineering & Cell Therapy
Medical Field: Cardiovascular
Est.: 2000
Stage: Pre-Clinical
MGVS develops unique products for very large patient populations who cannot be treated adequately with current therapeutic modalities, with a focus on cardiovascular related syndromes. The Company's therapeutic products utilize the patient's own (autologous) vascular cells, modified by genes that are operative in natural vascular processes. MGVS currently has two products at different stages of development: 1) angiogenesis therapy for patients with arterial obstructive diseases of the legs and the heart; 2) bio-engineered grafts for use in bypass surgery in the legs and in hemodialysis access site. MGVS has recently closed a round of 4 million dollars, which will bring it to the conclusion of Phase I studies.
Contact Info:
Dr. Moshe Flugelman, CEO
972-4-825-0832
972-4-825-0841

GeneGrafts Ltd.
Sector: Biotechnology
Sub-Sector: Tissue Engineering & Cell Therapy
Medical Field: Cardiovascular
Est.: 2003
Stage: Seed
http://www.genegrafts.com
GeneGrafts is a new biotechnology company, developing a novel therapy for atrial fibrillation (AF). Atrial fibrillation is the most common cardiac arrhythmia affecting 2.3 million Americans. Conventional therapy for AF is based on medications taken daily, with significant side effects. GeneGrafts is developing a cell therapy approach using autologous (extracted from the patient) genetically modified cells that are delivered to the patient's heart by catheterization. The treatment is localized and involves a single procedure.
Contact Info:
Dr. Yair Feld, CEO
972-4-854-6618
972-4-850-1246

TheraVitae Ltd.
Sector: Biotechnology
Sub-Sector: Tissue Engineering & Cell Therapy
Medical Field: Cardiovascular
Est.: 2003
Stage: Clinical
http://www.theravitae.com
TheraVitae is an emerging healthcare company focused on using the patient's own cells in order to treat a variety of disorders, especially cardiovascular diseases. We are an international company, based in Bangkok, Thailand and Kiryat Weizmann, Israel, benefiting from collaborations with eminent physicians and scientists, affiliated with well-known medical and academic institutions. We are committed to helping our patients by developing and utilizing cutting-edge science at its highest standards.
TheraVitae offers novel, state-of-the-art therapies to people for whom existing medical procedures cannot be used or were not successful. We will offer hope to people who refuse to accept that they have been condemned to physical incapacitation, spending the rest of their lives in suffering because they cannot enjoy the latest medical technologies as the latter are not available to them in their country.
The company is at clinical development stage and focused on the development of cellular therapies for cardiovascular and other disorders. The first product developed by the Company is based on autologous (patient's own cells) endothelial progenitor cells and it is in clinical trial for the treatment of angina pectoris.
Contact Info:
Valentin Fulga, MD, CEO
enquiries@theravitae.com
7, Pinchas Sapir St. Ness Ziona, 74410, Israel
972-8-940-9170
972-8-940-9167

NesStent Ltd.
Sector: Medical Devices
Sub-Sector: Disposable; Implantable; Therapeutic Devices
Medical Field: Cardiovascular
Est.: 2003
Stage: Seed
NesStent Ltd is a start up company developing unique Stenting solutions and devices including:
1. A new stent concept for coronary bifurcations
2. A new catheter concept for precision delivery of stents to bifurcations or other hard to stent locations. 3. A novel stent to be inserted to the Carotid bifurcation diverting emboli in the Carotid artery, and by doing so preventi strokes.
Contact Info:
jonathan Eting
POBox 345, OR Yehuda 60200, Israel
972-3-634-4254
972-3-634-1565

B-Balloon Ltd.
Sector: Medical Devices
Sub-Sector: Disposable; Implantable; Therapeutic Devices
Medical Field: Cardiovascular
Est.: 2004
Stage: Pre-Clinical
http://www.bballoon.com
B-Balloon Ltd., an Israeli medical device start-up, develops dedicated stents and stent delivery systems that will safely allow the placing of stents in Ostial and Bifurcation lesions. These lesions are considered two of the biggest unresolved challenges in Percutaneus Coronary Intervention. Nevertheless, B-Balloon's devices are not limited to the coronaries and may be used in other vessels.
Contact Info:
Ziv Ehrenfeld, COO
ziv@bballoon.com
972-3-634-9990
972-3-634-9910

Existent Ltd.
Sector: Medical Devices
Sub-Sector: Disposable; Implantable; Therapeutic Devices
Medical Field: Cardiovascular
Est.: 2003
Stage: Seed
Existent is developing a new cardiovascular stent.
Contact Info:
Dr. Motty Beyar, CEO
eilat@existent-med.com
Hasadnaot 3 st., Herzeliya 46728, Israel
972-9-970-4300
972-9-970-4318

Derio Medical Instruments Ltd.
Sector: Medical Devices
Sub-Sector: Disposable; Implantable;
Medical Field: Cardiovascular



Reprinted from the Israel High-Tech & Investment Report July 2006

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